New research indicates that short periods of intense physical activity in the form of high-intensity interval training (HIIT) can reverse frailty in mice, suggesting the same may be true for humans.
“…it’s possible that high-intensity interval training can help enhance quality of life and capacity to be healthy…”
The new study used two groups of a dozen mice, each 24 months old, which correlates roughly to 65 years old in human terms. All the mice had been sedentary up until that age. While cautioning that the study was done in mice, the authors say the results could be applicable to humans.
“We know that being frail or being at risk for becoming frail puts people at increased risk of dying and comorbidity,” says senior author Bruce R. Troen, senior author on the study and a professor and chief of the geriatrics and palliative medicine division at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
“These results show that it’s possible that high-intensity interval training can help enhance quality of life and capacity to be healthy,” he says.
The results were striking, with mice exhibiting “dramatic” improvements in numerous measurements, including strength and physical performance.
One of the most significant findings was that by the end of the study, five of six mice found to be frail or pre-frail at baseline improved, and four were no longer frail.
“Those four mice who had exhibited the kinds of deficits that correlate to frailty in humans improved to a completely robust level,” Troen says. “The HIIT actually reversed frailty in them.”
Researchers developed mouse equivalents for measures that assess human frailty, including ways to evaluate grip strength, endurance and gait speed, so that they could establish baseline levels and then compare those with results once the study was complete.
“Because the performance measures for the mice are directly relevant to clinical parameters, we think this program of exercise is quite applicable to humans,” Troen says. “We’re laying a foundation so we can do this in people and so we can understand how to tailor it to individuals so they can successfully implement this.”
Similar to the way that an athletic trainer might individualize a fitness program for a client, intensity levels were tailored for each mouse.
“While the mice are genetically identical, they aren’t phenotypically…